ProSci

Aurora B Antibody [AURKB/1521]

Product Code:
 
PSI-33-614
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG2b
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
AURKB/1521
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunofluorescence (IF)
  • Western Blot (WB)
Shipping:
 
blue ice
Storage:
 
Aliquot and Store at -20C. Avoid freez-thaw cycles.
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Western blot testing of 1) a partial recombinant protein and 2) human liver lysate with Aurora B antibody (clone AURKB/1521). Predicted molecular weight: 39-45 kDa
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Western blot testing of 1) a partial recombinant protein and 2) human liver lysate with Aurora B antibody (clone AURKB/1521). Predicted molecular weight: 39-45 kDa

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PSI-33-614-100ug100ug£765.00
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Further Information

Additional Names:
Aurora kinase B, Aurora 1, Aurora- and IPL1-like midbody-associated protein 1, AIM-1, Aurora/IPL1-related kinase 2, ARK-2, Aurora-related kinase 2, STK-1, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase aurora-B, AURKB, AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5
Application Note:
Western blot: 0.5-1 ug/ml

Flow Cytometry: 0.5-1ug/10e6 cells in 0.1ml

IF: 1-2 ug/ml

Optimal dilution of the Aurora B antibody should be determined by the researcher.
Background:
Recognizes a protein of 39-45kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.2 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Amino acids 89-251 were used as the immunogen for this Aurora B antibody.
NCBI Gene ID #:
9212
NCBI Official Name:
aurora kinase B
NCBI Official Symbol:
AURKB
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein G affinity
Research Area:
Cancer,Cell Cycle,Signal Transduction
Swissprot #:
Q96GD4
User NOte:
Optimal dilutions for each application to be determined by the researcher