ProSci

Ly-6A/E Antibody [D7]

Product Code:
 
PSI-98-880
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
[D7]
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Immunocytochemistry (ICC)
  • Immunohistochemistry- Frozen Section (IHC-F)
  • Western Blot (WB)
Shipping:
 
blue ice
Storage:
 
Store vial at -20˚C
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PSI-98-880-0.5mg0.5mg£746.00
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Further Information

Additional Names:
Sca-1
Application Note:
Ly-6A/E Antibody [D7] for use in flow cytometry, immunohistochemistry, western blotting, immunoprecipitation, and costimulation assays.
Background:
Ly-6A/E, also known as Sca-1, is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes. In the periphery, Ly-6A/E exhibits a pattern of expression which is based on differences between the two allotypes. Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E+ resting peripheral lymphocytes whereas Ly-6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Ly-6A/E+ lymphocytes. The expression of Ly-6A/E is dramatically upregulated in all strains upon cellular activation. Studies with the monoclonal antibody D7 suggest that Ly-6A/E may be involved in B and T lymphocyte responses and it appears that the antigen may be required for T-cell receptor-mediated T-cell activation.
Buffer:
Supplied in PBS
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IL-2 dependent mouse (C57BL/6) cytotoxic T cell line CTL-L
NCBI Gene ID #:
110454
NCBI Official Name:
lymphocyte antigen 6 complex, locus A
NCBI Official Symbol:
Ly6a
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P05533
Research Area:
Innate Immunity,Stem Cell
SPECIFICITY:
Ly-6A/E
Swissprot #:
P05533
User NOte:
Optimal dilutions for each application to be determined by the researcher.