Further Information
6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase, 11418-, Catalase B, Glycoprotein 75, Melanoma antigen gp75, Tyrosinase-related protein 1, TRP, TRP-1, TRP1, TYRP1, CAS2, TYRP, TYRRP
Flow Cytometry: 0.5-1 ug/million cells in 0.1ml
Immunofluorescence: 1-2 ug/ml
Immunohistochemistry (Frozen only) : 0.5-1 ug/ml for 30 minutes at RT
The optimal dilution of the TRP1 antibody for each application should be determined by the researcher.
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
0.2 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
SK-MEL-23 cells were used as the immunogen for this TRP1 antibody.
7306
tyrosinase-related protein 1
TYRP1
Homo sapiens
Liquid
Protein G affinity chromatography
Cancer,Cell Cycle,Obesity,Signal Transduction
P17643
Optimal dilutions for each application to be determined by the researcher