ProSci

CD8a Antibody [53-6.7]

Product Code:
 
PSI-98-620
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
[53-6.7]
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Immunohistochemistry- Frozen Section (IHC-F)
  • Immunoprecipitation (IP)
Shipping:
 
blue ice
Storage:
 
Store vial at -20˚C
1 / 1

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PSI-98-620-0.5mg0.5mg£541.00
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Further Information

Additional Names:
Ly-2, Lyt-2, Ly-35, Ly-B, T8
Application Note:
CD8a Antibody [53-6.7] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, depletion, and blocking assays.
Background:
In the mouse, CD8 exists in two forms ? (i) a CD8 heterodimer composed of an alpha chain (CD8alpha) and a beta chain (CD8beta); and (ii) a homodimer of two alpha chains. The heterodimer is found on the surface of essentially all thymocytes and the ?suppressor/cytotoxic? subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8alpha without CD8beta. It has been suggested that CD8+beta- T cells mature extrathymically, while development of the CD8alpha+beta+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8alpha+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2.
Buffer:
Supplied in PBS
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Spleen cells or thymocyte membranes
NCBI Gene ID #:
12525
NCBI Official Name:
CD8 antigen, alpha chain
NCBI Official Symbol:
Cd8a
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P01731
Research Area:
Immunology
SPECIFICITY:
CD8alpha
Swissprot #:
P01731
User NOte:
Optimal dilutions for each application to be determined by the researcher.