ProSci

DC-SIGN Antibody

Product Code:
 
PSI-33-022
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Shipping:
 
blue ice
Storage:
 
Aliquot and Store at -20C. Avoid freez-thaw cycles.
1 / 1
Western blot testing of human samples with DC-SIGN antibody at 2ug/ml.
❮❯

Western blot testing of human samples with DC-SIGN antibody at 2ug/ml.

No additional charges, what you see is what you pay! *

CodeSizePrice
PSI-33-022-100ug100ug£662.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • Show All

Further Information

Additional Names:
DC-SIGN Antibody: CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, CD209 antigen, C-type lectin domain family 4 member L
Application Note:
Western blot: 2-5 ug/ml

Provided assay concentrations are suggestions only, DC-SIGN antibody titration may be required for optimal results.
Background:
DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209, is part of the Lectin family of proteins. DC-SIGN is part of the innate immune response via its modulation of Toll-like Receptors. It is present on the surface of macrophages and dendritic cells and binds mannose carbohydrates, a class of PAMPS found on bacteria, fungi and viruses. PAMP stimulated DC-SIGN activates the Raf kinases Raf-1 and B-Raf. Raf-1 phosphorylates Ser276 of NF-kB p65 which serves as a binding site for histone acetyltransferases CREB-binding protein (CBP) and p300. Acetylation of NF-kB p65 leads to enhanced and prolonged anti-inflammatory cytokine IL-10 production.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A recombinant protein fragment from human DC-SIGN was used as the immunogen for this antibody.
NCBI Gene ID #:
30835
NCBI Official Name:
CD209 molecule
NCBI Official Symbol:
CD209
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein A purified antibody
Research Area:
Infectious Disease
Swissprot #:
Q9NNX6
User NOte:
Optimal dilutions for each application to be determined by the researcher