ProSci

CD80 Antibody [1G10]

Product Code:
 
PSI-98-845
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
[1G10]
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Shipping:
 
blue ice
Storage:
 
Store vial at 2-8˚C
1 / 1
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PSI-98-845-0.5mg0.5mg£524.00
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Further Information

Additional Names:
B7-1, Ly-53
Application Note:
CD80 Antibody [1G10] for use in flow cytometry, immunoprecipitation, and blocking assays.
Background:
CD80 (B7-1) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed by dendritic cells, monocytes, and peritoneal macrophages. Expression of CD80 on B cells is upregulated after activation by various means including stimulation by LPS, IL-4, and surface Ig receptor crosslinking with peak expression occurring between 48 and 72 hours post-activation. The interaction of CD80 with its ligands, CD28 and CD152 (CTLA-4), provides a potent costimulatory signal for T cells activated through the CD3/T cell receptor complex. The monoclonal antibody 1G10 blocks binding of CTLA-4 to CD80 but it does not block stimulation of T cells by natural antigen-presenting cells.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Activated 5C2 cells
NCBI Gene ID #:
12519
NCBI Official Name:
CD80 antigen
NCBI Official Symbol:
Cd80
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
Q00609
Research Area:
Immunology,Signal Transduction
SPECIFICITY:
CD80
Swissprot #:
Q00609
User NOte:
Optimal dilutions for each application to be determined by the researcher.