ProSci

CD54 Antibody [YN1/1.7.4]

Product Code:
 
PSI-98-817
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rat
Antibody Isotype:
 
IgG2b
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
[YN1/1.7.4]
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Immunocytochemistry (ICC)
  • Immunohistochemistry- Frozen Section (IHC-F)
  • Western Blot (WB)
Shipping:
 
blue ice
Storage:
 
Store vial at -20˚C
1 / 1
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PSI-98-817-0.5mg0.5mg£613.00
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Further Information

Additional Names:
ICAM-1, Ly-47
Application Note:
CD54 Antibody [YN1/1.7.4] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, blocking, and purification assays.
Background:
CD54, a member of the immunoglobulin superfamily of cell surface receptors and also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein that mediates important cell/cell interactions. CD54 is expressed on endothelial cells, dendritic cells, keratinocytes, and lymphocytes. Its expression is upregulated by inflammatory mediators such as IFN gamma, IL-1, TNF-alpha, lipopolysaccharide, and phorbol esters. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells contributes to antigen-specific T-cell activation, presumably by enhancing interactions between T cell and antigen-presenting cells. These adhesion reactions are mediated via the binding of CD54 to its major ligands, LFA-1 and Mac-1.
Buffer:
Supplied in PBS
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Mouse NS-1 cells
NCBI Gene ID #:
15894
NCBI Official Name:
intercellular adhesion molecule 1
NCBI Official Symbol:
Icam1
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P13597
Research Area:
Immunology,Signal Transduction
SPECIFICITY:
CD54
Swissprot #:
P13597
User NOte:
Optimal dilutions for each application to be determined by the researcher.