ProSci

CD5 Antibody [53-7.3]

Product Code:
 
PSI-98-608
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
[53-7.3]
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Immunohistochemistry- Frozen Section (IHC-F)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Shipping:
 
blue ice
Storage:
 
Store vial at 2-8˚C
1 / 1
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PSI-98-608-0.5mg0.5mg£469.00
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Further Information

Additional Names:
Lyt-1, Ly-1, Lymphocyte antigen 1, Ly-12, Ly-A, T1, Tp67
Application Note:
CD5 Antibody [53-7.3] for use in flow cytometry, immunohistochemistry, immunoprecipitation, ELISA, cytotoxicity, and blocking assays.
Background:
CD5, also known as Lyt-1, is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B-cell antigen CD72. The frequency of CD5+ B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells. Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Spleen cells or thymocyte membranes
NCBI Gene ID #:
12507
NCBI Official Name:
CD5 antigen
NCBI Official Symbol:
Cd5
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P13379
Research Area:
Cancer,Immunology,Signal Transduction
SPECIFICITY:
CD5
Swissprot #:
P13379
User NOte:
Optimal dilutions for each application to be determined by the researcher.