ProSci

CD22 Antibody [2D6]

Product Code:
 
PSI-98-682
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rat
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
[2D6]
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Shipping:
 
blue ice
Storage:
 
Store vial at -20˚C
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PSI-98-682-0.5mg0.5mg£702.00
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Further Information

Additional Names:
Lyb-8, Leu-14, BL-CAM
Application Note:
CD22 Antibody [2D6] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and activation assays.
Background:
CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B cell activation.
Buffer:
Supplied in PBS
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Splenic lymphocyte plasma membranes from CBA x C57 F1 mice
NCBI Gene ID #:
12483
NCBI Official Name:
CD22 antigen
NCBI Official Symbol:
Cd22
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P35329
Research Area:
Cancer,Stem Cell,Immunology
SPECIFICITY:
CD22
Swissprot #:
P35329
User NOte:
Optimal dilutions for each application to be determined by the researcher.