ProSci

CD152 Antibody [9H10]

Product Code:
 
PSI-98-911
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Hamster
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
[9H10]
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Immunocytochemistry (ICC)
  • Immunohistochemistry- Frozen Section (IHC-F)
Shipping:
 
blue ice
Storage:
 
Store vial at 2-8˚C
1 / 1
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PSI-98-911-0.5mg0.5mg£524.00
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Further Information

Additional Names:
CTLA-4, cytotoxic T-lymphocyte protein 4
Application Note:
CD152 Antibody [9H10] for use in flow cytometry, ELISA, blocking, and costimulation assays.
Background:
CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80 and CD86) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signaling through the TCR through its association with tyrosine phosphatases such as SHP-2.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein
NCBI Gene ID #:
12477
NCBI Official Name:
cytotoxic T-lymphocyte-associated protein 4
NCBI Official Symbol:
Ctla4
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P09793
Research Area:
Immunology
SPECIFICITY:
CD152
Swissprot #:
P09793
User NOte:
Optimal dilutions for each application to be determined by the researcher.