Further Information
Integrin alphaM, Mac-1alpha, Mac-1, Mo1, CR3, C3biR
CD11b Antibody [M1/70] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and blocking assays.
CD11b, the integrin alphaM subunit, combines with CD18, the integrin beta2 subunit, to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1/CD54. Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. Mac-1 expression is rapidly up-regulated on neutrophils after activation and in the same time period that CD62L is shed from the cell surface. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils. Cross-reaction of M1/70 to human CD11b has been observed on monocytes, polymorphonuclear leukocytes, and NK cells.
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
0.5 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes
16409
Integrin alpha M
Itgam
Mus musculus
Liquid
P05555
Immunology,Neuroscience,Signal Transduction
CD11b
P05555
Optimal dilutions for each application to be determined by the researcher.