ProSci

Bax Antibody [6A7]

Product Code:
 
PSI-99-623
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
[6A7]
Regulatory Status:
 
RUO
Target Species:
  • Bovine (Cattle)
  • Human
  • Monkey
  • Mouse
  • Rat
Application:
 
Flow Cytometry
Shipping:
 
blue ice
Storage:
 
Store vial at 2-8˚C
1 / 1
Total cell lysates from NIH/3T3 cells were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-Bax-UNLB (Cat. No. 99-623). Proteins were visualized using Goat Anti-Mouse IgG, Human ads-HRP secondary antibody and chemiluminescent detection.
❮❯

Total cell lysates from NIH/3T3 cells were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-Bax-UNLB (Cat. No. 99-623). Proteins were visualized using Goat Anti-Mouse IgG, Human ads-HRP secondary antibody and chemiluminescent detection.

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PSI-99-623-0.1mg0.1mg£505.00
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Further Information

Additional Names:
Apoptosis regulator BAX, BCL2 associated X protein
Application Note:
Bax Antibody [6A7] for use in flow cytometry, immunohistochemistry / immunocytochemistry, electron microscopy, western blotting, immunoprecipitation, and neutralization assays.
Background:
Bax is a 20-22 kDa member of the Bcl-2 family of proteins involved in regulation of programmed cell death, or apoptosis. In murine thymocytes, it is expressed primarily as a cytoplasmic protein. Over-expression of Bax promotes apoptosis by formation of homodimers and through heterodimerization with Bcl-2, an inhibitor of apoptosis. The monoclonal antibody 6A7 reacts with human, mouse and rat Bax but does not bind the soluble cytosolic form of Bax; however, treatment of cells with non-ionic detergents exposes the epitope and allows binding of 6A7 to monomeric forms of Bax but not Bax complexed with either Bcl-2 or Bcl-xL.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Bax peptide (a.a. 12-24) common to mouse, rat, and human
NCBI Gene ID #:
581/12028/24887
NCBI Official Name:
BCL2 associated X, apoptosis regulator
NCBI Official Symbol:
BAX
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q07812
Research Area:
Cancer,Cell Cycle,Obesity
SPECIFICITY:
Bax
Swissprot #:
Q07812
User NOte:
Optimal dilutions for each application to be determined by the researcher.