KIM-1 Antibody / TIM-1 / HAVCR1

Western blot: 0.5-1ug/ml,ELISA (Capture): 1-5ug/ml (human recombinant protein)

Optimal dilution of the TIM1 antibody should be determined by the researcher.

KIM1 (KIDNEY INJURY MOLECULE 1), also known as HAVCR1, HAVCR or TIM1, is a protein that in humans is encoded by the KIM1 gene. The gene is mapped to 5q33.3. Biochemical, mutational, and cell adhesion analyses confirm that TIM1 is capable of homophilic Tim-Tim interactions. The protein is indeed a receptor for the virus through the infection of canine osteogenic sarcoma cells expressing HAVCR1 with HAV. Using a monoclonal antibody to mouse Tim1, TIM1 is expressed after activation of naive T cells and on T cells differentiated in Th2-polarizing conditions. Ectopic expression of TIM1 during mouse T-cell differentiation leads to production of the Th2-type cytokine Il4, but not the Th1-type cytokine Ifng. TIM1-expressing epithelial cells internalized apoptotic bodies, and the protein is directly responsible for phagocytosis in cultured primary rat tubule epithelial cells and in porcine and canine epithelial cell lines.

Purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

Amino acids Q58-K289 from the human protein were used as the immunogen for the TIM1 antibody.

This TIM1 antibody is available for research use only.

Antigen affinity purified

Human

Q96D42