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CHP Applications - Fibrotic Conditions
Documents
Peptides
3Helix
CHP Applications - Skeletal Disease and Development
Documents
Peptides
3Helix
Empowering Collagen Targeting for the Diagnosis and Treatment of Human Conditions
Documents
Peptides
3Helix
Collagen is the most abundant protein in mammals. It is the major structural component of almost all organs and tissues. Excessive collagen remodeling is associated in a variety of chronic pathological conditions, such as cancer, arthritis, and fibrosis.
Documents
Proteins
3Helix
Collagen is the most abundant protein in mammals. It is the major structural component of almost all organs and tissues. Excessive collagen remodelling is associated in a variety of chronic pathological conditions, such as cancer, arthritis, and fibrosis.
Documents
Proteins
3Helix
Collagen hybridizing peptides allow for visualization of fibrotic tissue or any tissues with an increase of collagen turnover.
Videos
Peptides
3Helix
Collagen is the major building block in all load bearing tissues including tendon, ligament, bone, and cartilage. Mechanical injury to these tissues causes changes in collagen structure which can initiate pathological processes without detectable morphological changes at the macroscale. Using CHPs you can now visualize the mechanical damage to the triple helix.
Videos
Peptides
3Helix
The skeletal system has a large quantity of collagen, making visualization of skeletal development, disease and turnover with CHPs a perfect use case. Find out more at 3helix.com
Videos
Peptides
3Helix
Collagen has a unique triple helical structure that is unfolded in tissues during diseases, development, mechanical injury, and decellularization. 3Helix commercializes labeled collagen hybridizing peptide (CHP) that specifically binds to such unfolded collagen chains.
Videos
Peptides
3Helix
Every decellularization method may alter the composition and the micro-architecture of ECM, causing variations of the biological activity and mechanical integrity of the decellularized material. CHP specifically detects denatured collagen in the decellularized tissue/organ, enabling assessment of the effect of decellularization upon ECM at the molecular level.
Videos
Peptides
3Helix
Collagen has a unique triple helical structure that is unfolded in tissues during diseases, development, mechanical injury, and decellularization.
Documents
Proteins
3Helix